Gite shital shridhar, shinkar abstractabstract dattatraya manohar, saudagar ravindra bhanudas 1. Mucoadhesive drug delivery system free ebook download as powerpoint presentation. Buccal or sublingual regions within oral cavity can be used for systemic delivery of drugs. The api will be released close to the site of action with a consequent enhancement of bioavailability mucoadhesive drug delivery systems provide a means of enhancing retention at defined sites, if systemic uptake occurs the use of mucoadhesive polymers will not prevent a. In the present update on mucoadhesive polymers for ocular delivery dosage forms, the tremendous advances in the biochemistry of mucins, the development of new polymers, the use of drug complexes and other technological advances are discussed. Natural edible mucoadhesive polymers from various parts of plants and compared with synthetic mucoadhesive polymers teelavath mangilal1, k. Mucoadhesive drug delivery system adhesion polymers. Pdf mucoadhesive polymers and their mode of action. Thiolated chitosans recently, it has been shown that polymers with thiol groups provide much higher adhesive properties than polymers generally considered to be mucoadhesive. One of the most important features of the nasal route is that it avoids firstpass hepatic metabolism, thereby reducing metabolism. Formulation f6 containing gum olibanum with highest concentration showed good mucoadhesive strength 24. Mucoadhesive polymers in the treatment of dry x syndrome.
Mucoadhesive tablets from each batch, under a constant weight of 5 g, were then placed onto the mucosal membrane for 1 minute. Ravikumar4 1 p rof es,d p a tm nhc yu ivc l gt o hyderabad500007, telangana, india 2 prof esg v nmtly c h iw,k adp 516 02 a i. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. Koninklijke brill nv, leiden, 2009 keywords mucosa, mucoadhesion, mucoadhesive polymers, drug delivery 1.
In turbidimetric titration, a polymer with high affinity to mucin forms aggregates easily, which can be quantitatively determined by light scattering at 600 nm a 600. Preparation of buccal mucoadhesive controlled drug delivery systems of. A wide range of formulations has been proposed for the delivery of small molecules, but comparatively few have found their way onto the market. Mucoadhesive polymers and their mode of action semantic scholar.
The present research mainly focuses on the screening of different mucoadhesive polymers for the development of mucoadhesive tablets with intestinal target. The concept of mucoadhesive polymers has been introduced into the pharmaceutical. Type i is a single layer device with multidirectional drug release. Read mucoadhesive polymers in the design of nanodrug delivery systems for administration by nonparenteral routes. International conference on biofriendly polymers and polymer additives, budapest. Some of them also show phase transition near to physiological human body temperature. Formulation and evaluation of mucoadhesive drug delivery. The bioavailability of ophthalmic drugs is, however, very poor due to efficient protective mechanisms of the eye. This also focuses on mucoadhesive drug delivery systems available in the market 1.
These compositions are well suited, for example, for the delivery of anionic ophthalmic pharmaceuticals because they can provide clear solution in addition to substantivity. Moreover, these polymers can be modified to show solgel transition at desired temperature. Prior art in field of mucoadhesive dosage forms for buccal administration buccal mucoadhesive dosage forms can be categorized into three types based on their geometry. A more specific term than bioadhesion is mucoadhesion. Formulation and in vitro evaluation of mucoadhesive. Using in vitro and in vivo visometric data, mucoadhesive polymer interaction has been defined as polymercumin force of interaction in precorneal area. Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic. Novel mucoadhesive polymers in novel mucoadhesive polymer cases, existing mucoadhesive polymers have been modified, while in others, new materials are developed.
Chitosan and its derivatives for application in mucoadhesive. Based on the results obtained from this study a rank order of the most cited mucoadhesive polymers could be established. Formulation and evaluation of mucoadhesive buccal tablets. Theories, polymers, dosage forms, evaluation of mucoadhesive dosage forms. This type of dosage form suffers from significant drug loss due to swallowing. Thermoresponsive polymer an overview sciencedirect topics. Mucoadhesive drug delivery systems 3 the contact between the mucoadhesive and the mucous membrane, with spreading and swelling of the formulation, initiating its deep contact with the mucus layer hagerstrom, 2003. Means of improving the mucoadhesive properties of drug delivery system article pdf available may 2010 with 5,431 reads how we measure reads. Being a basic polymer, chitosan is mucoadhesive only at limited phs and. In addition to their mucoadhesive properties and their permeationenhancing effects, certain polymers are able to inhibit the protease activities in the intestine. Thus, the pharmaceutical industry has an interest in drug delivery systems formulated around the use of mucoadhesive polymers. The various mucoadhesive polymers used for the development of buccal delivery systems include cyanoacrylates, polyacrylic acid, sodium carboxymethylcellulose, hyaluronic acid, hydroxypropylcellulose, polycarbophil, chitosan and gellan. Introduction opical application of drugs to the eye is the most popular and wellaccepted route of administration for the treatment of various eye disorders. The api will be released close to the site of action with a consequent enhancement of bioavailability mucoadhesive drug delivery systems provide a means of enhancing retention at defined sites, if systemic uptake occurs the use of mucoadhesive polymers will.
Isolation, evaluation and toxicity studies of natural. Lectins lectins are naturally occurring proteins that play a fundamental role in biological recognition phenomena involving e residues. Within this study the mucoadhesive properties of various polymers have been evaluated by two different test systems. Formulation and evaluation of mucoadhesive drug delivery systems. All the ingredients except lubricants were mixed in the order of ascending weights and blended for 10 min in an inflated polyethylene pouch. Mucoadhesive agents are usually polymers containing hydrogen bonding groups that can be used in wet formulations or in dry powders for drug. Pdf the potential of mucoadhesive delivery system for sustained delivery. This makes the buccal cavity more suitable for mucoadhesive drug delivery. The mucoadhesive buccal films of ranitidine were prepared by solvent casting technique using polymers like hydroxy propyl methyl cellulose15 cps and poly vinyl pyrrolidone. The force required to detach the mucoadhesive tablet from the mucosa was regarded as the bioadhesive strength, and it was measured in terms of weight in grams. Pdf mucoadhesive polymers for enhancing retention in ocular. Three kinds of methods such as tensile strength test, mucin particle method and rheology were used to compare the quantitative mucoadhesion of mucoadhesive polymers. Bioadhesive polymeric platforms for transmucosal drug.
Dumore1 1dadasaheb balpande college of diploma in pharmacy, besa nagpur 2gurunanak college of pharmacy, nagpur need for injection would be a major advance in dental pain control, this research work was planned with there. Development of buccal drug delivery system based on mucoadhesive polymers khairnar g. A recent update bappaditya chatterjee 1, nursazreen amalina 1, pinaki sengupta 1, uttam kumar mandal 2 1 pharmaceutical technology, kulliyyah of pharmacy, international islamic university malaysia, kuantan 25200, malaysia. Bioadhesion, mucoadhesion, buccal drug delivery, thiolated polymers. Natural mucoadhesive polymers natural polymers, such as polysaccharides, can be distinguished. The potential of a mucoadhesive polymer as an ophthalmic vehicle is evaluated within the rabbit. Facile control of the ph of the mucin and mucoadhesive polymer solutions is one advantage of the turbidimetric titration method. A free powerpoint ppt presentation displayed as a flash slide show on id. Ocular drug delivery is a very challenging task faced by pharmaceutical scientists, inspite of the fact that eye is the most sensitive and accessible organ for the delivery of drugs. This also focuses on mucoadhesive drug delivery systems available in the market.
Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process. Evaluation of mucoadhesive polymers in ocular drug delivery. Mucoadhesive drug delivery system is a part of controlled delivery system. Hence, it is necessary to deepen the study of the polymers properties.
Mdds utilizes the property of bioahesion of certain watersoluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time. Hydrogels as mucoadhesive and bioadhesive materials. The nasal mucosal layer has a surface area of around 150200 cm2. A recent update bappaditya chatterjee1, nursazreen amalina1, pinaki sengupta1, uttam kumar mandal2 1pharmaceutical technology, kulliyyah of pharmacy, international islamic university malaysia, kuantan 25200, malaysia. The tablets were evaluated for hardness, weight variation, thickness, percentage of drug content, surface ph, invitro studies like swelling, mucoadhesive strength and drug release. Turbidimetric titration method was used to compare the mucoadhesive properties of the polymers. The present study involves preparation and characterization of mucoadhesive microspheres with famotidine as model drug for prolongation of gastric residence time. This also focuses on mucoadhesive drug delivery systems available in the. Like buccal cavity, nasal cavity also provides a potential site for the development of formulations where mucoadhesive polymers can play an important role. Formulation and evaluation of mucoadhesive drug delivery systems free download as powerpoint presentation. Formulation and development of mucoadhesive dental gel. Mucoadhesive polymers, both synthetic and biological, have a history. Formulation and development of mucoadhesive dental gel shital nishant shende 1. Quantitative evaluation of mucoadhesive polymers to compare.
Precorneal clearance of a mucoadhesive polymer solution carbopol 934p is compared to that of an. Adhesion of a matter to this layer is hence called mucoadhesion. Mucoadhesive polymers and ocular lubricants basicmedical key. The various mucoadhesive polymers used for the development of buccal delivery systems include cyanoacrylates, polyacrylic acid, sodium carboxymethylcellulose, hyaluronic acid, hydroxypropylcellulose, polycarbophil. Polymers used in the mucoadhesive drug delivery system. Introduction mucoadhesive polymers are synthetic or natural macromolecules which are capable of attaching to mucosal surfaces. Bioadhesive and mucoadhesive polymers authorstream presentation. Mucosa, mucoadhesion, mucoadhesive pol ymers, drug delivery.
Evaluation of mucoadhesive polymers in ocular drug. Mucoadhesion is widely investigated as a promising strategy for prolonged and enhanced drug delivery through various membranes grabovac et al, 2005. Pdf bioadhesive polymeric platforms for transmucosal. Advances in mucoadhesion and mucoadhesive polymers. The history of pharmaceutical mucoadhesives started more than 40 years ago.
The overall aim of this thesis was to prepare and characterise different polymercoated liposomes and investigate the correlation between the mucoadhesive and potential hydrating properties of the liposomal formulations. Most mucosal surfaces such as in the gut or nose are covered by a layer of mucus. A focus on mucoadhesive polymers and their application in. The major categories are wetting theory, adsorption theory, diffusion theory, electrostaticic theory, and fracture theory. Thermoresponsive polymers are the most comprehensively studied responsive polymers because of their unique property of solgel transition above certain temperature. Mucoadhesive polymers are synthetic or natural macromolecules that are capable of attaching to mucosal surfaces. Matrix tablets of tramadol hcl were formulated using different mucoadhesive polymers namely guar gum, xanthan gum and methocel hpmc k15m and hpmc k100m. Jul 22, 2016 occurrence of polymermucin force of interaction has been reported when mucoadhesive polymers interact with corneal epithelium. Dec 27, 2010 excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups andor non. Quantitative evaluation of mucoadhesive polymers to. In some cases, such as for ocular or vaginal formulations, the delivery system is mechanically attached over the membrane. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups andor non.
One of the most important features of the nasal route is that it avoids firstpass hepatic metabolism. Mucoadhesive drug delivery systems has received noticeable attentions in the pharmaceutical field, resulted in the adhesion of the drug to the tissue for a prolonged period of time. Compositions comprising cationic polysaccharide polymers and anionic therapeutic agents which can have enhanced substantivity to mucosal surfaces are disclosed. Isolation, evaluation and toxicity studies of natural edible. Comparison of the mucoadhesive properties of various polymers. Direct interaction between a human digestive protease and. Mucoadhesive polymeric hydrogels for nasal delivery of. Oral mucosa, mucoadhesion, bioadhesive polymer, dosage form. The microspheres were prepared by the wo emulsification solvent evaporation method using mucoadhesive polymers sod. The nasal mucosa provides a potentially good route for systemic drug delivery. Pdf mucoadhesive polymers for enhancing retention in. The mucoadhesive polymers play the key role in determining the mucoadhesive ability of a dosage form. Innovative methods and applications in mucoadhesion.